Guanabana (Soursop)

Why FDA issued it

NOTE: The revision of this Import Alert (IA) dated 05/18/2022 updates the reason for alert, guidance section, agency contacts, and product description section. Changes to the import alert are bracketed by asterisks (***). ***Soursop is a tropical fruit of Annona muricata, an evergreen tree (also known as graviola, guyabano, guanabana, Brazilian pawpaw, corossol or prickly custard apple) that is native to Central and tropical South America. The fruit, along with leaves and bark, contain neurotoxic compounds called acetogenins. The seeds contain high levels of acetogenins rendering them inedible. In the scientific literature, acetogenins are described as associated with neurodegenerative disorders.*** ***This alert was created in June 1990 in response to a complaint/injury report and subsequent FDA investigation, after thirty-four adults and children drank "Rain Drop" Guanabana Drink impor

Quoted from the “Reason for Alert” section of the FDA page for 31-03, mirrored 30 August 2026. The quotation is truncated at the length this copy carries.